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The research in the Goldstein laboratory is focused on the intersection between cancer biology, stem cell biology and metabolism. During his graduate work, Dr. Goldstein described the isolation of epithelial progenitor cells from mouse and human prostate tissue (PNAS) and demonstrated the capacity or progenitor cells to initiate prostate cancer in response to oncogenic transformation (Science). Following up on this work, Dr. Goldstein and colleagues determined that prostate cancer can evolve from a basal cell of origin to a luminal-like tumor-propagating cell population (PNAS). More recently, the Goldstein laboratory has demonstrated that chronic inflammation in the human prostate is associated with an expansion of rare luminal progenitor cells that can initiate aggressive prostate cancer (Cell Reports). These findings help to explain why chronic inflammation increases prostate cancer risk. The lab continues to interrogate the mechanisms responsible for cancer initiation, progression and treatment-resistance.