EXPANSION OF LUMINAL PROGENITOR CELLS IN THE AGING MOUSE AND HUMAN PROSTATE

In a new study published in Cell Reports, co-first authors Preston Crowell and Jonathan Fox from the Goldstein Lab led a team of researchers at UCLA and UT Southwestern to determine the mechanisms by which aging increases disease risk in the prostate. The group determined that a specific type of progenitor cell (luminal progenitor cell) is increased in the aging mouse and human prostate. The luminal progenitor cells have previously been shown to be able to develop into prostate cancer in response to oncogenic insults, which means that there are more cells at risk for developing into cancer in the aging prostate. Future studies will be aimed at determining what causes the age-related increase in luminal progenitor cells so that we can develop strategies to slow or prevent this process and reduce the risk of disease in the prostate. Read the press release here.

Mass cytometry reveals species-specific differences and a new level of complexity for immune cells in the prostate

In a new study published in the American Journal of Clinical and Experimental Urology, Jonathan Fox and colleagues at UCLA utilized mass cytometry to characterize immune cells in the mouse and human prostate. The group used mass cytometry and software analysis tools to elucidate a greater degree of immune cell heterogeneity in the mouse prostate than previously reported. The authors found fundamental differences between the immune compartment of the mouse and human prostate, as the mouse prostate is myeloid-dominant and the human prostate is lymphoid-dominant. Finally, the study revealed considerable differences in the immune compartments between patients. Future studies will be aimed at determining the functional role of various immune populations in prostate aging and tumorigenesis.